In 1968, Dr. Kilmer McCully, a Harvard researcher, reported that a genetic defect that caused sharp elevations in homocysteine led to early, aggressive atherosclerosis and coronary heart disease. This was the first of many studies that pointed to homocysteine as an independent risk factor for heart disease.
To make good clinical use of the last half-century's scientific study of inflammation, we need to re-think inflammation and understand it more correctly as a repair deficit--something blocking the innate ability of the body to heal.
Hemoglobin A1c (HgbA1c) is one of the most useful and important biomarkers available to us as clinicians. It accurately predicts the risk of diabetes long before the disease advances, and it can be used to assess the impact of any form of therapy aimed at regulating blood sugar and insulin sensitivity.
Measurement of first morning urine pH gives a good indication of the body's mineral reserve and its acid/alkaline state. It's inexpensive, easy to teach to patients, and gives important clinical information.