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Prevention Practice Pearls

Homocysteine: Rethinking a Predictive Biomarker

By Russell Jaffe, MD, PhD - Vol. 15, No. 1. Spring, 2014

In 1968, Dr. Kilmer McCully, a Harvard researcher, reported that a genetic defect that caused sharp elevations in homocysteine led to early, aggressive atherosclerosis and coronary heart disease. This was the first of many studies that pointed to homocysteine as an independent risk factor for heart disease.

Inflammation Revealed, Tamed and Resolved

By Russell Jaffe, MD, Contributing Writer - Vol. 14, No. 3. Fall, 2013

To make good clinical use of the last half-century's scientific study of inflammation, we need to re-think inflammation and understand it more correctly as a repair deficit--something blocking the innate ability of the body to heal.

Hemoglobin A1C: The “Swiss Army Knife” Of Diabetes Assessment

By Russell Jaffe, MD, PhD | Contributing Writer

Hemoglobin A1c (HgbA1c) is one of the most useful and important biomarkers available to us as clinicians. It accurately predicts the risk of diabetes long before the disease advances, and it can be used to assess the impact of any form of therapy aimed at regulating blood sugar and insulin sensitivity.

Evaluating GI Transit Time

By Russell M. Jaffe, MD / Contributing Writer - Vol. 11, No. 4. Winter, 2010
Gastrointestinal transit time—the interval between consumption of food and it’s elimination as feces—is a handy indicator of digestive health. It is easy and inexpensive to measure, requiring just a handful of activated charcoal capsules.

First Morning Urine pH: A Window on Acid:Alkaline Balance

By Russell M. Jaffe, MD | Contributing Writer - Vol. 10, No. 1. Spring, 2009

Measurement of first morning urine pH gives a good indication of the body's mineral reserve and its acid/alkaline state. It's inexpensive, easy to teach to patients, and gives important clinical information.

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